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Ask ur doubts here for medicos and Medical studentsPosted 1 year ago #
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Dr.Ruby can u tell me wat is Fibrates and its Uses ????????????Posted 1 year ago #
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dr-ruby
offlineMemberAs asked mentioned previously, Fibrates are a group of cholesterol lowering drugs under the Fibric Acid derivative class. Clofibrate being 1st generation, Gemfibrozil and fenofibrate are newer ones.
MOA: Basically being a ligand for PPAR-alpha (Peroxisome proliferator activated receptor alpha) , it increases Lipolysis of the Lipoprotein Triglyceride. ie: by enhancing effect of Lipoprotein lipase enzyme.( this is sufficient to memorise as MOA )
It decreases intracellular lipolysis hence decreasing amount of lipid in blood.
Causes decrease in VLDL secretion from liver, hence lowering blood values.
Shows moderate increase in HDL.
When given with drugs like statins, the combined effect on lowering Triglyceride and increasing HDL is notable.
LDL shows slight reduction. Some pts even show slight increase, but with combined medication this is ruled out.
Toxicity rarely seen-skin rash, GI, Hypokalemia, high alk PO4.
Always order liver function test prior to administering fibrates. Avoid in hep/nephro cases
Interfere with warfarin, anticoagulants- so dose adjustmnt for these meds required
Be on watch for Myopathy when fibrate given with Statin.
Dosage: Fenofibrate usually 65 mg tab TDS with/ just before each meal
Gemfibrozil is 600 mg tab usually OD/ BD with food
Contraindicated: Biliary tract illnesses.
Gallstone risk(increases cholesterol excretion in bile)
Obese patients.
Pls add if you come across more or do correct me if needed. (The above is as per my understanding and prior reading during Exit)
AS RESPONSE TO NIACIN DISCUSSION in prior post:
Niacin contraindicated in DM unless on insulin, in arrythmias, can cause hypotension in Hypertensives. NOT USED ACTIVELY ANYMORE UNLESS ABSOLUTELY NECESSARY.Posted 1 year ago # -
dr-ruby
offlineMemberMain use of Fibrates come in cases with High Triglyceride and dysbetalipoproteinemia. In the latter, fibrates are shown to increase lipo-protein, hence balancing the dysbetalipoproteinemia.Posted 1 year ago # -
Dr.Ruby that was a very Valid information for me and i cud get the piece of cake
Thank u ......I think it was a lot a information though
Anyways i cud learn the mechanism and the drug content.......................... And again thanks for the information about Newer drugs ......It was really very useful..........
Urs sincerely
Dr-lokkuPosted 1 year ago # -
dr-ruby
offlineMemberGlad to hear you benefited. I simply penned down every information I could recall for you. There are pages written in texts about these. If however one sticks to what information I gave, it should be well sufficient for any examination-theory or practical- thruout med career. All summarised in one page, thats how I feel pharmac should be approached.Posted 1 year ago # -
vaishnavi
offlineMemberIN A PROGRAM A DR. SAID IN KIDNEY TRANSPLANTATION
HLA MATCHING
IS NECESSARY.WHT DOES IT MEAN???IS THS CRITERIA SEEN FOR ANY OTHER ORGAN TRANSPLANTATION????Posted 1 year ago # -
HLA as such is the Major Histo compatibility of Humans
.Like the Cells of the Human for Identifying its type . Actually Speaking HLA stands for Human Leucocyte Antigen Like the real identity of a cell .Like which type it belongs to .In simple words its like ur a tamilian and there is one more tamilian they dont belong to the same caste thats the difference , there HLA typing comes in picture where there is caste , got it
About the typing
What is HLA Typing?
Human Leukocyte Antigen (HLA) typing is a testing process that is used to match patients and donors for cord blood or bone marrow transplants.HLA antigens are proteins found in most cells in our body. Our immune system uses these proteins or markers to recognize which cells belong in our body and which do not. If the immune system determines a cell as not belonging to the body, the cell is attacked. Thus, HLA typing is done to reduce the risk of the transplanted stem cell being attacked by the immune system of the recipient. A close match between the patient's HLA antigens and the donor's can reduce the risk of the patient's immune cells attacking the donor's cells or vice versa. HLA typing is usually done for all allogeneic transplants, using a blood sample.
Relationship Chances of matching
Sibling - sibling 25%
Parent - child 50 %
Cousins 6.25%
got it
Regards
Dr-lokkuPosted 1 year ago # -
vaishnavi
offlineMemberTANX NA.........U INFO WAS EASY FOR ME TO UNDERSTAND & IM CLEAR NOW......
Posted 1 year ago # -
Anyways thanks Ms.Vaishanavi its a Age Old Question
Regards
Dr-lokkuPosted 1 year ago #
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